Normally, all campaigns that you create will follow the SMS Settings and Email Settings in the General Settings of your Coupon Reach software account.
But there's a way that you can change the phone number as well as the email sender for a particular campaign.
Yes, you can set up a separate email account for each campaign by going to the Campaign Properties.
Each campaign has its own Email Settings when you access its properties. You'll notice that they have their own SMS Settings and Email Settings:
When you change something from those settings, the change/s will only apply to that campaign. So you can use a separate number as well as a separate email sender for that campaign.